MicroRNA-29, a key regulator of collagen expression in systemic sclerosis.

@article{Maurer2010MicroRNA29AK,
  title={MicroRNA-29, a key regulator of collagen expression in systemic sclerosis.},
  author={Britta Maurer and Joanna Stanczyk and Astrid Juengel and Alfiya Akhmetshina and Michelle Trenkmann and Matthias Brock and Otylia M Kowal-Bielecka and Renate Erika Gay and Beat Michel and J{\"o}rg H. W. Distler and S. Kirsten Gay and Oliver Distler},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 6},
  pages={1733-43}
}
OBJECTIVE To investigate the role of microRNA (miRNA) as posttranscriptional regulators of profibrotic genes in systemic sclerosis (SSc). METHODS MicroRNA, which target collagens, were identified by in silico analysis. Expression of miRNA-29 (miR-29) was determined by TaqMan real-time polymerase chain reaction analysis of skin biopsy and fibroblast samples from SSc patients and healthy controls as well as in the mouse model of bleomycin-induced skin fibrosis. Cells were transfected with… CONTINUE READING
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