MicroRNA-27a Promotes Inefficient Lysosomal Clearance in the Hippocampi of Rats Following Chronic Brain Hypoperfusion

@article{Che2016MicroRNA27aPI,
  title={MicroRNA-27a Promotes Inefficient Lysosomal Clearance in the Hippocampi of Rats Following Chronic Brain Hypoperfusion},
  author={Hui Che and Yan Yan and Xiao-Hui Kang and Fei Guo and Mei-Ling Yan and Huai-Lei Liu and Xu Hou and Tong Liu and De-Kang Zong and Lin-Lin Sun and Ya-Nan Bao and Li-hua Sun and Bingjia Yang and Jing Ai},
  journal={Molecular Neurobiology},
  year={2016},
  volume={54},
  pages={2595-2610}
}
Chronic brain hypoperfusion (CBH) induces the accumulation of abnormal cellular proteins, accompanied by cognitive decline, and the autophagic-lysosomal system is abnormal in dementia. Whether CBH accounts for autophagic-lysosomal neuropathology remains unknown. Here, we show that CBH significantly increased the number of autophagic vacuoles (AVs) with high LC3-II levels, but decreased SQSTM1 and cathepsin D levels in the hippocampi of rats following bilateral common carotid artery occlusion… CONTINUE READING

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