MicroRNA-26a is Strongly Down-regulated in Melanoma and Induces Cell Death through Repression of Silencer of Death Domains (SODD)

@inproceedings{Reuland2013MicroRNA26aIS,
  title={MicroRNA-26a is Strongly Down-regulated in Melanoma and Induces Cell Death through Repression of Silencer of Death Domains (SODD)},
  author={Steven N. Reuland and Shilo M. Smith and Lynne T. Bemis and N. B. Goldstein and Adam Almeida and Katie A. Partyka and Victor E. Marquez and Qinghong Zhang and David A. Norris and Yiqun G Shellman},
  booktitle={The Journal of investigative dermatology},
  year={2013}
}
Melanoma is an aggressive cancer that metastasizes rapidly and is refractory to conventional chemotherapies. Identifying microRNAs (miRNAs) that are responsible for this pathogenesis is therefore a promising means of developing new therapies. We identified miR-26a through microarray and quantitative reverse-transcription-PCR (qRT-PCR) experiments as an miRNA that is strongly downregulated in melanoma cell lines as compared with primary melanocytes. Treatment of cell lines with miR-26a mimic… CONTINUE READING
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