MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection

@inproceedings{Sahu2017MicroRNA2,
  title={MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection},
  author={Sanjaya Kumar Sahu and Manish C. Kumar and Sohini Chakraborty and Srijon Kaushik Banerjee and Ranjeet Kumar and Pushpa L. Gupta and Kuladip Jana and Umesh Datta Gupta and Zhumur Ghosh and Manikuntala Kundu and Joyoti Basu},
  booktitle={PLoS pathogens},
  year={2017}
}
For efficient clearance of Mycobacterium tuberculosis (Mtb), macrophages tilt towards M1 polarization leading to the activation of transcription factors associated with the production of antibacterial effector molecules such as nitric oxide (NO) and proinflammatory cytokines such as interleukin 1 β (IL-1β) and tumor necrosis factor α (TNF-α). At the same time, resolution of inflammation is associated with M2 polarization with increased production of arginase and cytokines such as IL-10. The… CONTINUE READING
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