MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein

@inproceedings{Zhu2012MicroRNA26abAT,
  title={MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein},
  author={Ying Zhu and Yang Lu and Yiqing Li and Jingjing Liu and Tuan-jie Li and Jian-Rong Yang and Chunxian Zeng and S C Zhuang},
  booktitle={Nucleic acids research},
  year={2012}
}
The functional association between intronic miRNAs and their host genes is still largely unknown. We found that three gene loci, which produced miR-26a and miR-26b, were embedded within introns of genes coding for the proteins of carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase (CTDSP) family, including CTDSPL, CTDSP2 and CTDSP1. We conducted serum starvation-stimulation assays in primary fibroblasts and two-thirds partial-hepatectomies in mice, which revealed that miR… CONTINUE READING

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