MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells.

@article{Kwon2015MicroRNA26a26bCOX2MIP2LR,
  title={MicroRNA-26a/-26b-COX-2-MIP-2 Loop Regulates Allergic Inflammation and Allergic Inflammation-promoted Enhanced Tumorigenic and Metastatic Potential of Cancer Cells.},
  author={Yoojung Kwon and Youngmi Kim and Sangkyung Eom and Misun Kim and Deokbum Park and Hyuna Kim and Kyeonga Noh and Hansoo Lee and Yun Sil Lee and Jongseon Choe and Young Myeong Kim and Dooil Jeoung},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 22},
  pages={14245-66}
}
Cyclooxgenase-2 (COX-2) knock-out mouse experiments showed that COX-2 was necessary for in vivo allergic inflammation, such as passive cutaneous anaphylaxis, passive systemic anaphylaxis, and triphasic cutaneous allergic reaction. TargetScan analysis predicted COX-2 as a target of miR-26a and miR-26b. miR-26a/-26b decreased luciferase activity associated… CONTINUE READING