MicroRNA-25 regulates small cell lung cancer cell development and cell cycle through cyclin E2.

@article{Zhao2014MicroRNA25RS,
  title={MicroRNA-25 regulates small cell lung cancer cell development and cell cycle through cyclin E2.},
  author={Zhengyuan Zhao and Juntao Liu and Changlei Wang and Yi Wang and Youguo Jiang and Min Guo},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 11},
  pages={7726-34}
}
PURPOSE We intended to examine the underlying mechanism of microRNA-25 (miR-25) in regulating small cell lung cancer (SCLC). METHODS The miR-25 expression was measured by quantitative RT-PCR (qRT-PCR) in 5 SCLC cell lines and 9 human SCLC tissues. In SCLC cell line H510A cells, endogenous miR-25 was downregulated by stable transfection of antisense oligonucleotide of miR-25 (miR-25-as). Then the effects of miR-25 downregulation on SCLC growth, invasion and chemoresistance were assessed by MTT… CONTINUE READING
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