MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7.

@article{Li2013MicroRNA25FA,
  title={MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7.},
  author={Qiang Li and Chaoxia Zou and Chendan Zou and Zhongjing Han and Haifeng Xiao and Huiyan Wei and Wei Wang and Lei Zhang and Xueying Zhang and Qingchao Tang and Chunjing Zhang and Ji Tao and Xi-shan Wang and Xu Gao},
  journal={Cancer letters},
  year={2013},
  volume={335 1},
  pages={
          168-74
        }
}
Because it is a member of the miR-106b~25 cluster, microRNA-25 (miR-25) is known to be dysregulated in human cancers. However, the expression and role of miR-25 in colon cancer remain unclear. In this study, miR-25 was found to be down-regulated in human colon cancer tissues when compared to those in matched, non-neoplastic mucosa tissues. Functional studies revealed that restoration of miR-25 expression inhibited cell proliferation and migration. In contrast, miR-25 inhibition could promote… CONTINUE READING

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