MicroRNA-223 regulates FOXO1 expression and cell proliferation.

@article{Wu2012MicroRNA223RF,
  title={MicroRNA-223 regulates FOXO1 expression and cell proliferation.},
  author={Lihui Wu and Huihui Li and Cheng You Jia and Wei Cheng and Mei Yu and Min Peng and Yuanqing Zhu and Qianlei Zhao and Yi Wei Dong and Kang Chen Shao and Anle Wu and Xing Zhong Wu},
  journal={FEBS letters},
  year={2012},
  volume={586 7},
  pages={
          1038-43
        }
}
In HCT116 colorectal cancer cells, HeLa cervical cancer cells and HuH-7 hepatoma cells, miR-223 is expressed at a low level. Through infection with lentivirus containing miR-223 precursor, miR-223 [corrected] was overexpressed in all these cells. Interestingly, the expression levels of FOXO1 mRNA and protein, and phosphorylation levels became significantly lower than those of their control. FOXO1 was down-regulated mainly in the cytoplasm, while the nuclear FOXO1 level became relatively high… CONTINUE READING

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 75 CITATIONS, ESTIMATED 70% COVERAGE

miRNA-223-3p regulates NLRP3 to promote apoptosis and inhibit proliferation of hep3B cells

  • Experimental and therapeutic medicine
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Clinical role of circulating miR-223 as a novel biomarker in early diagnosis of cancer patients.

  • International journal of clinical and experimental medicine
  • 2015
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

MicroRNAs in colorectal cancer: from diagnosis to targeted therapy.

  • Asian Pacific journal of cancer prevention : APJCP
  • 2014
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2012
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 6 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES