MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.

@article{Ying2015MicroRNA223IA,
  title={MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.},
  author={Wei Wei Ying and Alexander Tseng and Richard Cheng-An Chang and Andrew Morin and Tyler Brehm and Karen Triff and Vijayalekshmi Nair and Guoqing Zhuang and Hui Song and Srikanth Kanameni and Haiqing Wang and Michael C. Golding and Fuller W Bazer and Robert S. Chapkin and Stephen Safe and Beiyan Zhou},
  journal={The Journal of clinical investigation},
  year={2015},
  volume={125 11},
  pages={
          4149-59
        }
}
Polarized activation of adipose tissue macrophages (ATMs) is crucial for maintaining adipose tissue function and mediating obesity-associated cardiovascular risk and metabolic abnormalities; however, the regulatory network of this key process is not well defined. Here, we identified a PPARγ/microRNA-223 (miR-223) regulatory axis that controls macrophage polarization by targeting distinct downstream genes to shift the cellular response to various stimuli. In BM-derived macrophages, PPAR… CONTINUE READING

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