MicroRNA 22 regulates cell cycle length in cerebellar granular neuron precursors.

@article{Berenguer2013MicroRNA2R,
  title={MicroRNA 22 regulates cell cycle length in cerebellar granular neuron precursors.},
  author={Jordi Berenguer and Antonio Manuel Herrera and Laura Vuolo and Blanca Torroba and Franc Llorens and Lauro Sumoy and Sebasti{\'a}n Pons},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 14},
  pages={
          2706-17
        }
}
During cerebellum development, Sonic hedgehog (Shh)-induced proliferation of cerebellar granular neuronal precursors (CGNPs) is potently inhibited by bone morphogenetic proteins (BMPs). We have previously reported the upregulation of TIEG-1 and Mash1, two antimitotic factors that modulate MYCN transcription and N-Myc activity, in response to BMP2. To gain further insight into the BMP antimitotic mechanism, we used microRNA (miRNA) arrays to compare the miRNAs of CGNPs proliferating in response… CONTINUE READING

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