MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart

Abstract

MicroRNAs (miRs) are small non- coding RNA molecules controlling a plethora of biological processes such as development, cellular survival and senescence. We here determined miRs differentially regulated during cardiac postnatal development and aging. Cardiac function, morphology and miR expression profiles were determined in neonatal, 4 weeks, 6 months and… (More)
DOI: 10.1007/s11357-012-9407-9

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