MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1

@article{Menghini2009MicroRNA2M,
  title={MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1},
  author={R. Menghini and V. Casagrande and M. Cardellini and E. Martelli and A. Terrinoni and F. Amati and M. Vasa-Nicotera and A. Ippoliti and G. Novelli and G. Melino and R. Lauro and M. Federici},
  journal={Circulation},
  year={2009},
  volume={120},
  pages={1524-1532}
}
Background— Aging is a major risk factor for the development of atherosclerosis and coronary artery disease. Through a microarray approach, we have identified a microRNA (miR-217) that is progressively expressed in endothelial cells with aging. miR-217 regulates the expression of silent information regulator 1 (SirT1), a major regulator of longevity and metabolic disorders that is progressively reduced in multiple tissues during aging. Methods and Results— miR-217 inhibits SirT1 expression… Expand
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