MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog.

@article{Li2014MicroRNA21SG,
  title={MicroRNA-21 stimulates gastric cancer growth and invasion by inhibiting the tumor suppressor effects of programmed cell death protein 4 and phosphatase and tensin homolog.},
  author={Ling Li and Liya Zhou and Yuwen Li and San-ren Lin and Ciprian Tomuleasa},
  journal={Journal of B.U.ON. : official journal of the Balkan Union of Oncology},
  year={2014},
  volume={19 1},
  pages={228-36}
}
PURPOSE MicroRNA-21 (miR-21) is abnormally expressed in many solid cancers, such as gastric adenocarcinoma, and regulates some targets involved in cancer initiation and progression. In this study, we investigated the function of miR-21 in two gastric cancer cell lines, as well as its potential targeting of the tumor suppressor genes phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 (PDCD4). METHODS The first step was to use quantitative (q) RTPCR in order to verify the… CONTINUE READING