MicroRNA-21 modulates the levels of reactive oxygen species by targeting SOD3 and TNFα.

@article{Zhang2012MicroRNA21MT,
  title={MicroRNA-21 modulates the levels of reactive oxygen species by targeting SOD3 and TNFα.},
  author={Xiangming Zhang and Wooi-Loon Ng and Ping Wang and Linlin Tian and Erica F Werner and Huichen Wang and Paul W. Doetsch and Ya Wang},
  journal={Cancer research},
  year={2012},
  volume={72 18},
  pages={4707-13}
}
MicroRNA-21 (miR-21) is an oncomir overexpressed in most human tumors in that it promotes malignant growth and progression by acting on multiple targets. Here, we broaden the impact of miR-21 in cancer by showing that it regulates the formation of reactive oxygen species (ROS) that promote tumorigenesis. Key targets of miR-21 in mediating this function were SOD3 and TNFα. We found that miR-21 inhibited the metabolism of superoxide to hydrogen peroxide, produced either by endogenous basal… CONTINUE READING
43 Citations
23 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 23 references

Targeting DNAPK and ATM with miR-101 sensitizes tumors to radiation

  • D Yan, W Ng, X Zhang, P Wang, Z Zhang, Y Mo
  • PLoS ONE 2010;5:e11397
  • 2010
1 Excerpt

Similar Papers

Loading similar papers…