MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas.

@article{Corsten2007MicroRNA21KD,
  title={MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas.},
  author={Maarten F. Corsten and Rafael de Carvalho Miranda and Randa Kasmieh and Anna M. Krichevsky and Ralph Weissleder and Khalid Shah},
  journal={Cancer research},
  year={2007},
  volume={67 19},
  pages={8994-9000}
}
Despite the development of new glioma therapies that allow for tumor-targeted in situ delivery of cytotoxic drugs, tumor resistance to apoptosis remains a key impediment to effective treatment. Mounting evidence indicates that microRNAs (miRNA) might play a fundamental role in tumorigenesis, controlling cell proliferation and apoptosis. In gliomas, microRNA-21 (miR-21) levels have been reported to be elevated and their knockdown is associated with increased apoptotic activity. We hypothesized… CONTINUE READING

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