MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand.

@article{Sayed2010MicroRNA21IA,
  title={MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand.},
  author={Danish Sayed and Minzhen He and Chull Hong and Shumin Gao and Shweta Rane and Zhi Yang and M. Serry Abdellatif},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 26},
  pages={
          20281-90
        }
}
MicroRNA-21 (miR-21) is highly up-regulated during hypertrophic and cancerous cell growth. In contrast, we found that it declines in cardiac myocytes upon exposure to hypoxia. Thus, the objective was to explore its role during hypoxia. We show that miR-21 not only regulates phosphatase and tensin homologue deleted on chromosome 10 (PTEN), but also targets Fas ligand (FasL). During prolonged hypoxia, down-regulation of miR-21 proved necessary and sufficient for enhancing expression of both… CONTINUE READING
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