MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach.

@article{Parikh2012MicroRNA21IP,
  title={MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach.},
  author={V. N. Parikh and Richard C. Jin and Sabrina Rabello and Natali Gulbahce and Kevin H White and Andrew Hale and Katherine A. Cottrill and Rahamthulla S. Shaik and Aaron B Waxman and Y Y Zhang and Bradley A Maron and Jochen C. Hartner and Yuko Fujiwara and Stuart H Orkin and Kathleen J. Haley and Albert-L{\'a}szl{\'o} Barab{\'a}si and Joseph Loscalzo and Stephen Y Chan},
  journal={Circulation},
  year={2012},
  volume={125 12},
  pages={1520-32}
}
BACKGROUND Pulmonary hypertension (PH) is driven by diverse pathogenic etiologies. Owing to their pleiotropic actions, microRNA molecules are potential candidates for coordinated regulation of these disease stimuli. METHODS AND RESULTS Using a network biology approach, we identify microRNA associated with multiple pathogenic pathways central to PH. Specifically, microRNA-21 (miR-21) is predicted as a PH-modifying microRNA, regulating targets integral to bone morphogenetic protein (BMP) and… CONTINUE READING
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