MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease

@inproceedings{Yelamanchili2010MicroRNA21DT,
  title={MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease},
  author={Sowmya V. Yelamanchili and Amrita Datta Chaudhuri and Lu Chen and Huangui Xiong and Howard S. Fox},
  booktitle={Cell Death and Disease},
  year={2010}
}
MicroRNAs (miRNAs) have important roles in regulating a plethora of physiological and pathophysiogical processes including neurodegeneration. In both human immunodeficiency virus (HIV)-associated dementia in humans and its monkey model simian immunodeficiency virus encephalitis (SIVE), we find miR-21, a miRNA largely known for its link to oncogenesis, to be significantly upregulated in the brain. In situ hybridization of the diseased brain sections revealed induction of miR-21 in neurons. miR… CONTINUE READING

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