MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.

@article{Kim2017MicroRNA21DS,
  title={MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2.},
  author={Richard Yong Kim and Jay Christopher Horvat and James W. Pinkerton and Malcolm Ronald Starkey and Ama T. Essilfie and Jemma R. Mayall and Prema M. Nair and Nicole G Hansbro and Bernadette Jones and Tatt Jhong Haw and Krishna P. Sunkara and Thi Hiep Nguyen and Andrew Gregory Jarnicki and Simon J Keely and Joerg Mattes and Ian M. Adcock and Paul S Foster and Philip M Hansbro},
  journal={The Journal of allergy and clinical immunology},
  year={2017},
  volume={139 2},
  pages={519-532}
}
BACKGROUND Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently required, however, their development is hampered by a lack of understanding of the mechanisms of disease pathogenesis. Steroid-insensitive asthma is associated with respiratory tract infections and noneosinophilic endotypes, including… CONTINUE READING