MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

@article{Thum2008MicroRNA21CT,
  title={MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts},
  author={Thomas Thum and Carina Gross and Jan Fiedler and Thomas Fischer and Stephan Kissler and Markus Bussen and Paolo Galuppo and Steffen Just and Wolfgang Rottbauer and Stefan Frantz and Mirco Castoldi and J{\"u}rgen Soutschek and Victor E. Koteliansky and Andreas Rosenwald and Michiel A. Basson and Jonathan D. Licht and John T. G. Pena and Sara H. Rouhanifard and Martina U. Muckenthaler and Thomas Tuschl and Gail Roberta Martin and Johann Bauersachs and Stefan Engelhardt},
  journal={Nature},
  year={2008},
  volume={456},
  pages={980-984}
}
MicroRNAs comprise a broad class of small non-coding RNAs that control expression of complementary target messenger RNAs. Dysregulation of microRNAs by several mechanisms has been described in various disease states including cardiac disease. Whereas previous studies of cardiac disease have focused on microRNAs that are primarily expressed in cardiomyocytes, the role of microRNAs expressed in other cell types of the heart is unclear. Here we show that microRNA-21 (miR-21, also known as Mirn21… 
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