MicroRNA-205 targets SMAD4 in non-small cell lung cancer and promotes lung cancer cell growth in vitro and in vivo

@inproceedings{Zeng2017MicroRNA205TS,
  title={MicroRNA-205 targets SMAD4 in non-small cell lung cancer and promotes lung cancer cell growth in vitro and in vivo},
  author={Yuanyuan Grace Zeng and Jianjie Zhu and Dan Dan Shen and Hualong Qin and Zhe Lei and Wei Li and Zeyi Liu and Jianan Huang},
  booktitle={Oncotarget},
  year={2017}
}
Despite advances in diagnosis and treatment, the survival of non-small cell lung cancer (NSCLC) patients remains poor; therefore, improved understanding of the disease mechanism and novel treatment strategies are needed. Downregulation of SMAD4 and dysregulated expression of miR-205 have been reported. However, the relationship between them remains unclear. We investigated the effect of microRNA (miR)-205 on the expression of SMAD4 in NSCLC. Knockdown and overexpression of SMAD4 promoted or… CONTINUE READING

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