MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4.

@article{Wang2013MicroRNA2045pRE,
  title={MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD4.},
  author={Ye Wang and Wenfeng Li and Xinjie Zang and Nan Chen and Ting Liu and Panagiotis A. Tsonis and Yusen Huang},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 1},
  pages={323-32}
}
PURPOSE To investigate the role of microRNA (miRNA) in regulating epithelial-to-mesenchymal transition (EMT) during human posterior capsule opacification (PCO). METHODS A miRCURY LNA microRNA array was used to evaluate the miRNA profiles of human PCO tissues and normal attached lens epithelial cells (LECs). An in vitro human donor capsular bag model was used to investigate the role of miRNAs in the EMT during PCO. The expression of SMAD4, phospho-SMAD2/3, and a panel of EMT markers was… CONTINUE READING

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