MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents.

@article{Cochrane2009MicroRNA200cMI,
  title={MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-targeting chemotherapeutic agents.},
  author={Dawn R Cochrane and Nicole S. Spoelstra and Erin N. Howe and Steven K. Nordeen and Jennifer K Richer},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 5},
  pages={1055-66}
}
The transcription factor ZEB1 is normally not expressed in epithelial cells. When inappropriately expressed in carcinomas, ZEB1 initiates epithelial to mesenchymal transition due to its ability to repress E-cadherin and other genes involved in polarity. Recently, ZEB1 and ZEB2 have been identified as direct targets of the microRNA-200c family. We find that miR-200c levels are high in well-differentiated endometrial, breast, and ovarian cancer cell lines, but extremely low in poorly… CONTINUE READING
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