MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model.

@article{Murray2013MicroRNA200bDO,
  title={MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model.},
  author={Anne R Murray and Qian Chen and Yusuke Takahashi and Kevin K. Zhou and Kyoungmin Park and Jian-xing Ma},
  journal={Investigative ophthalmology & visual science},
  year={2013},
  volume={54 3},
  pages={1689-97}
}
PURPOSE MicroRNAs (miRNAs) are known to participate in post-transcriptional regulation of gene expression and are involved in multiple pathogenic processes. Here, we identified miRNA expression changes in the retinas of Akita mice, a genetic model of type 1 diabetes, and investigated the potential role of miRNA in diabetic retinopathy. METHODS Visual function of Akita and control mice was evaluated by electroretinography. MiRNA expression changes in the retinas of Akita mice were identified… CONTINUE READING

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