MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.

@article{Kato2007MicroRNA192ID,
  title={MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.},
  author={Mitsuo Kato and Jane Zhang and Mei Wang and Linda L. Lanting and Hang Yuan and John J. Rossi and Rama Natarajan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 9},
  pages={3432-7}
}
Key features of diabetic nephropathy (DN) include the accumulation of extracellular matrix proteins such as collagen 1-alpha 1 and -2 (Col1a1 and -2). Transforming growth factor beta1 (TGF-beta), a key regulator of these extracellular matrix genes, is increased in mesangial cells (MC) in DN. By microarray profiling, we noted that TGF-beta increased Col1a2 mRNA in mouse MC (MMC) but also decreased mRNA levels of an E-box repressor, deltaEF1. TGF-beta treatment or short hairpin RNAs targeting… CONTINUE READING
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