MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition

@article{Li2015MicroRNA19TE,
  title={MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition},
  author={Jing Li and Sheng Yang and Wen Yan and Jie Yang and Yu-juan Qin and Xiao-Lin Lin and Rao-Ying Xie and Sheng-chun Wang and Wen Jun Jin and Fei Gao and Jun-Wen Shi and W Zhao and Jun-shuang Jia and Hong-Fen Shen and Jie-Rong Ke and Bin Liu and Yi-qiao Zhao and Wen-Hua Huang and Kai-Tai Yao and Dan-Juan Li and Dong Xiao},
  journal={Laboratory Investigation},
  year={2015},
  volume={95},
  pages={1056-1070}
}
The miR-19 family (miR-19a and miR-19b-1) are key oncogenic components of the miR-17-92 cluster. Overexpression of miR-19 is strongly associated with cancer invasion and metastasis, and poor prognosis of cancer patients. However, the underlying mechanisms remain largely unknown. In the present study, we found that enforced expression of miR-19 including miR-19a and miR-19b-1 triggered epithelial–mesenchymal transition (EMT) of lung cancer cells A549 and HCC827 as shown by mesenchymal-like… CONTINUE READING
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