MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells.

@article{Qased2013MicroRNA18aUA,
  title={MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells.},
  author={Abu Baker Qased and Heqing Yi and Nan Liang and Shumei Ma and Shixing Qiao and Xiaodong Liu},
  journal={Molecular medicine reports},
  year={2013},
  volume={7 2},
  pages={559-64}
}
Autophagy is an evolutionarily conserved, multi-step lysosomal degradation process in which a cell degrades its own long-lived proteins and damaged organelles. Ataxia telangiectasia mutated (ATM) has recently been shown to upregulate the process of autophagy. Previous studies showed that certain microRNAs, including miR-18a, potentially regulate ATM in cancer cells. However, the mechanisms behind the modulation of ATM by miR-18a remain… CONTINUE READING
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