MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers

@inproceedings{Krutilina2013MicroRNA18aIH,
  title={MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers},
  author={Raisa I. Krutilina and WenLin Sun and Aarti Sethuraman and Martin Giles Brown and Tiffany N Seagroves and Lawrence M Pfeffer and Tatyana Nikolaevna Ignatova and Meiyun Fan},
  booktitle={Breast Cancer Research},
  year={2013}
}
IntroductionIn breast cancer, distinct expression profiles of microRNAs (miRNAs) have been associated with molecular subgroups and clinicopathological characteristics, implicating a diagnostic and prognostic role of miRNAs. However, the biological functions of deregulated miRNAs in tumor progression are not yet completely defined. In this study, we investigated the function of miR-18a in regulating breast cancer metastasis through the hypoxia-inducible factor 1α (HIF1A)–dependent hypoxic… CONTINUE READING
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