MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers

@article{Imam2010MicroRNA185ST,
  title={MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers},
  author={J Saadi Imam and Kalyan Chakravarthy Buddavarapu and Jennifer S. Lee-Chang and Suthakar Ganapathy and Charles C. Camosy and Y Chen and Manjeet K. Rao},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={4971-4979}
}
Homeobox genes encode transcription factors that are essential for normal development and are often dysregulated in cancers. The molecular mechanisms that cause their misregulation in cancers are largely unknown. In this study, we investigate the mechanism by which the Six1 homeobox protein, which has a crucial role during development, is frequently deregulated in several poor outcome, aggressive, metastatic adult human cancers, including breast cancer, ovarian cancer, hepatocellular carcinoma… CONTINUE READING

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