MicroRNA-185-5p mediates regulation of SREBP2 expression by hepatitis C virus core protein.


AIM To investigate the molecular mechanism for regulation of cholesterol metabolism by hepatitis C virus (HCV) core protein in HepG2 cells. METHODS HCV genotype 1b core protein was cloned and expressed in HepG2 cells. The cholesterol content was determined after transfection. The expression of sterol regulatory element binding protein 2 (SREBP2) and the… (More)
DOI: 10.3748/wjg.v21.i15.4517