MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma

  title={MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma},
  author={Alfa H. C. Bai and Till Milde and Marc Remke and Claudio G. Rolli and Thomas Hielscher and Y Jae Cho and Marcel Kool and Paul A. Northcott and Manfred Jugold and Alexandr V Bazhin and Stefan B. Eichm{\"u}ller and Andreas E Kulozik and Armin Pscherer and Axel Benner and Michael D. Taylor and Scott L. Pomeroy and Ralf Kemkemer and Olaf Witt and Andrey Korshunov and Peter Lichter and Stefan M. Pfister},
  journal={Acta Neuropathologica},
The contribution of microRNAs to the initiation, progression, and metastasis of medulloblastoma (MB) remains poorly understood. Metastatic dissemination at diagnosis is present in about 30% of MB patients, and is associated with a dismal prognosis. Using microRNA expression profiling, we demonstrate that the retinal miR-183–96–182 cluster on chromosome 7q32 is highly overexpressed in non-sonic hedgehog MBs (non-SHH-MBs). Expression of miR-182 and miR-183 is associated with cerebellar midline… CONTINUE READING


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