MicroRNA-181b regulates NF-κB-mediated vascular inflammation.

  title={MicroRNA-181b regulates NF-κB-mediated vascular inflammation.},
  author={Xinghui Sun and Basak Icli and A K M Khyrul Wara and Nathan Belkin and Shaolin He and Lester Kobzik and G. Matthew Hunninghake and Miguel Pinilla Vera and Timothy S. Blackwell and Rebecca Baron and Mark W. Feinberg},
  journal={The Journal of clinical investigation},
  volume={122 6},
EC activation and dysfunction have been linked to a variety of vascular inflammatory disease states. The function of microRNAs (miRNAs) in vascular EC activation and inflammation remains poorly understood. Herein, we report that microRNA-181b (miR-181b) serves as a potent regulator of downstream NF-κB signaling in the vascular endothelium by targeting importin-α3, a protein that is required for nuclear translocation of NF-κB. Overexpression of miR-181b inhibited importin-α3 expression and an… CONTINUE READING
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