MicroRNA-181b regulates NF-κB-mediated vascular inflammation.

@article{Sun2012MicroRNA181bRN,
  title={MicroRNA-181b regulates NF-κB-mediated vascular inflammation.},
  author={Xinghui Sun and Basak Icli and A K M Khyrul Wara and Nathan Belkin and Shaolin He and Lester Kobzik and G. Matthew Hunninghake and Miguel Pinilla Vera and Timothy S. Blackwell and Rebecca Baron and Mark W. Feinberg},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 6},
  pages={1973-90}
}
EC activation and dysfunction have been linked to a variety of vascular inflammatory disease states. The function of microRNAs (miRNAs) in vascular EC activation and inflammation remains poorly understood. Herein, we report that microRNA-181b (miR-181b) serves as a potent regulator of downstream NF-κB signaling in the vascular endothelium by targeting importin-α3, a protein that is required for nuclear translocation of NF-κB. Overexpression of miR-181b inhibited importin-α3 expression and an… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 139 extracted citations

Similar Papers

Loading similar papers…