MicroRNA-181a inhibits autophagy by targeting Atg5 in hepatocellular carcinoma.

@article{Yang2018MicroRNA181aIA,
  title={MicroRNA-181a inhibits autophagy by targeting Atg5 in hepatocellular carcinoma.},
  author={Jun Yang and Youzhao He and Niankuan Zhai and Sheng Ding and Jianping Li and Zhihai Peng},
  journal={Frontiers in bioscience},
  year={2018},
  volume={23},
  pages={
          388-396
        }
}
Available evidence suggests that autophagy may serve as a tumor suppressor in cases of chronic liver disease and liver cirrhosis and that autophagic deficiency may lead to hepatocellular carcinoma (HCC). Recent studies suggested that the development of several tumor types could be regulated by microRNA-181a. However, the role of miR-181a in the autophagy of HCC remains unclear. In this study, we aimed to investigate the role of miR-181a in the autophagy of HCC. We found that the mRNA expression… CONTINUE READING
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