MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure

  title={MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure},
  author={Geert C. van Almen and Wouter Verhesen and Rick E.W. van Leeuwen and Mathijs van de Vrie and Casper Eurlings and Mark W. M. Schellings and Melissa Swinnen and Jack P. M. Cleutjens and Marc A. M. J. van Zandvoort and Stephane Heymans and Blanche Schroen},
  booktitle={Aging cell},
To understand the process of cardiac aging, it is of crucial importance to gain insight into the age-related changes in gene expression in the senescent failing heart. Age-related cardiac remodeling is known to be accompanied by changes in extracellular matrix (ECM) gene and protein levels. Small noncoding microRNAs regulate gene expression in cardiac development and disease and have been implicated in the aging process and in the regulation of ECM proteins. However, their role in age-related… CONTINUE READING
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