MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke.

@article{Liu2013MicroRNA1792CM,
  title={MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke.},
  author={Xian Shuang Liu and Michael Chopp and Xin Li Wang and Li Zhang and Ann Hozeska-Solgot and Tao Tang and Haifa Kassis and Rui Lan Zhang and Charles Zhi-kai Chen and Jennifer Xu and Zheng Gang Zhang},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 18},
  pages={12478-88}
}
The role of microRNAs (miRNAs) in mediating adult neurogenesis after stroke has not been extensively studied. The present study investigated the function of the miR17-92 cluster in adult neural progenitor cells after experimental stroke. We found that stroke substantially up-regulated miR17-92 cluster expression in neural progenitor cells of the adult mouse. Overexpression of the miR17-92 cluster either in cultured ischemic neural progenitor cells or in the subventricular zone (SVZ) of ischemic… CONTINUE READING
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