MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4

@inproceedings{Lang2016MicroRNA15bRM,
  title={MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4},
  author={Alexander E. Lang and Susanne Grether-Beck and Madhurendra Singh and Fabian Kuck and Sascha Jakob and Andreas Kefalas and Simone Altinoluk-Hamb{\"u}chen and Nina Graffmann and Maren Schneider and Antje Lindecke and Heidi Brenden and Ingo Felsner and Hakima Ezzahoini and Alessandra Marini and Sandra Weinhold and Andrea Vierkoetter and Julia Tigges and Stephan Schmidt and Kai St{\"u}hler and Karl K{\"o}hrer and Markus Uhrberg and Judith Haendeler and Jean Krutmann and Roland P. Piekorz},
  booktitle={Aging},
  year={2016}
}
Mammalian sirtuins are involved in the control of metabolism and life-span regulation. Here, we link the mitochondrial sirtuin SIRT4 with cellular senescence, skin aging, and mitochondrial dysfunction. SIRT4 expression significantly increased in human dermal fibroblasts undergoing replicative or stress-induced senescence triggered by UVB or gamma-irradiation. In-vivo, SIRT4 mRNA levels were upregulated in photoaged vs. non-photoaged human skin. Interestingly, in all models of cellular… CONTINUE READING
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