MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis by Targeting O-GlcNAc Transferase.

@article{Liu2017MicroRNA15bST,
  title={MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis by Targeting O-GlcNAc Transferase.},
  author={Ruiqiong Liu and Xiaofeng Ma and Li Chen and Yang Yang and Yi Zeng and Juntao Gao and Wei Jiang and Fang Zhang and Daojing Li and Buxing Han and Ranran Han and Rongfang Qiu and Wei Huang and Yingshu Wang and Junwei Hao},
  journal={Journal of immunology},
  year={2017},
  volume={198 7},
  pages={
          2626-2639
        }
}
IL-17-producing Th17 cells have gradually become considered as key factors in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS). Although the involvement of certain microRNAs in the development of MS has been reported, their role in Th17-driven autoimmunity is still poorly understood. In this study, we identified microRNA (miR)-15b as an important factor in Th17-associated effects and determined that the expression of miR-15b is significantly downregulated in MS… CONTINUE READING

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