MicroRNA-155 regulates the Th17 immune response by targeting Ets-1 in Behçet's disease.

@article{Na2016MicroRNA155RT,
  title={MicroRNA-155 regulates the Th17 immune response by targeting Ets-1 in Behçet's disease.},
  author={So Young Na and Mi-Jin Park and Sun Mi Park and E H Lee},
  journal={Clinical and experimental rheumatology},
  year={2016},
  volume={34 6 Suppl 102},
  pages={S56-S63}
}
OBJECTIVES The goal of this study was to investigate whether microRNA-155 might be a potential therapeutic target for Behçet's disease (BD). METHODS Expression levels of miR-155 were quantified using TaqMan microRNA assays in peripheral blood mononuclear cells and in isolated CD4+ T cells from BD patients and healthy controls. To identify targets of miR-155, luciferase reporter assays and western blotting were performed. The effect of miR-155 on Th17 polarisation was analysed in patients with… CONTINUE READING