MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development.

@article{OConnell2010MicroRNA155PA,
  title={MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development.},
  author={Ryan M O'Connell and Daniel J Kahn and William Sidney Gibson and June L Round and Rebecca Lynn Scholz and Aadel A Chaudhuri and Melissa E. Kahn and D. Susmitha Rao and David Baltimore},
  journal={Immunity},
  year={2010},
  volume={33 4},
  pages={
          607-19
        }
}
Mammalian noncoding microRNAs (miRNAs) are a class of gene regulators that have been linked to immune system function. Here, we have investigated the role of miR-155 during an autoimmune inflammatory disease. Consistent with a positive role for miR-155 in mediating inflammatory responses, Mir155(-/-) mice were highly resistant to experimental autoimmune encephalomyelitis (EAE). miR-155 functions in the hematopoietic compartment to promote the development of inflammatory T cells including the T… CONTINUE READING
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