MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells.

@article{Ceppi2009MicroRNA155MT,
  title={MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells.},
  author={Maurizio Ceppi and Patr{\'i}cia M Pereira and Isabelle Dunand-Sauthier and Emmanu{\`e}le Barras and Walter Reith and Manuel A. S. Santos and Philippe Pierre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 8},
  pages={
          2735-40
        }
}
In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-derived dendritic cells. Among these miRNAs, miR-155 is highly up-regulated during maturation. Using LNA silencing combined to microarray technology, we have identified the Toll-like receptor/interleukin… CONTINUE READING
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