MicroRNA-155 knockout mice are susceptible to Mycobacterium tuberculosis infection.

@article{Iwai2015MicroRNA155KM,
  title={MicroRNA-155 knockout mice are susceptible to Mycobacterium tuberculosis infection.},
  author={Hiroki Iwai and Keiji Funatogawa and Kazunori Matsumura and Masako Kato-Miyazawa and Fumiko Kirikae and Kotaro Kiga and Chihiro Sasakawa and Tohru Miyoshi-Akiyama and Teruo Kirikae},
  journal={Tuberculosis},
  year={2015},
  volume={95 3},
  pages={246-50}
}
MicroRNAs (miRNAs) are short, conserved, non-coding RNA molecules that repress translation, followed by the decay of miRNA-targeted mRNAs that encode molecules involved in cell differentiation, development, immunity and apoptosis. At least six miRNAs, including microRNA-155 (miR-155), were up-regulated when born marrow-derived macrophages from C57BL/6 mice were infected with Mycobacterium tuberculosis Erdman. C57BL/6 mice intravenously infected with Erdman showed up-regulation of miR-155 in… CONTINUE READING
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