MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.

@article{Dudda2013MicroRNA155IR,
  title={MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.},
  author={Jan C. Dudda and Bruno Salaun and Yun Ji and Douglas C Palmer and Gwennaelle C Monnot and Estelle Merck and Caroline Boudousqui{\'e} and Daniel T Utzschneider and Thelma M. Escobar and Rachel Perret and Stefan A Muljo and Michael Walter Hebeisen and Nathalie Rufer and Dietmar Zehn and Alena Donda and Nicholas P Restifo and Werner Held and Luca Gattinoni and Pedro Romero},
  journal={Immunity},
  year={2013},
  volume={38 4},
  pages={
          742-53
        }
}
MicroRNAs (miRNAs) regulate the function of several immune cells, but their role in promoting CD8(+) T cell immunity remains unknown. Here we report that miRNA-155 is required for CD8(+) T cell responses to both virus and cancer. In the absence of miRNA-155, accumulation of effector CD8(+) T cells was severely reduced during acute and chronic viral infections and control of virus replication was impaired. Similarly, Mir155(-/-) CD8(+) T cells were ineffective at controlling tumor growth… CONTINUE READING
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