MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis

@inproceedings{Alivernini2016MicroRNA155IB,
  title={MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis},
  author={Stefano Alivernini and M Kurowska-Stolarska and Barbara Tolusso and Roberta Benvenuto and Aziza Elmesmari and Silvia Canestri and Luca Petricca and Antonella Mangoni and Anna Laura Fedele and Clara Di Mario and Maria Rita Gigante and Elisa Gremese and Iain B. Mcinnes and Gianfranco Ferraccioli},
  booktitle={Nature communications},
  year={2016}
}
MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell population in ACPA+ RA. MiR-155 is highly expressed in RA B cells from patients with synovial tissue containing ectopic germinal centres compared with diffuse synovial tissue. MiR… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Tumour necrosis factor inhibition versus rituximab for patients with rheumatoid arthritis who require biological treatment (ORBIT): an openlabel, randomised controlled, non-inferiority, trial

  • D Porter
  • Lancet 388,
  • 2016

Comprehensive analysis of miRNA expression in T-cell subsets of rheumatoid arthritis patients reveals defined signatures of naive and memory Tregs

  • K Smigielska-Czepiel
  • Genes Immun
  • 2014

Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses

  • White, A C.
  • J. Immunol
  • 2014

Stimulation of the B - cell receptor activates the JAK 2 / STAT 3 signaling pathway in chronic lymphocytic

  • J. S. Poovassery, G. A. Bishop
  • leukemia cells Blood
  • 2014

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

  • U Rozovski
  • Blood 123,
  • 2014

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