MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells

@article{Tsuyama2015MicroRNA153RT,
  title={MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells},
  author={J. Tsuyama and J. Bunt and L. Richards and H. Iwanari and Y. Mochizuki and T. Hamakubo and T. Shimazaki and H. Okano},
  journal={Stem Cell Reports},
  year={2015},
  volume={5},
  pages={365 - 377}
}
Summary Mammalian neural stem/progenitor cells (NSPCs) sequentially generate neurons and glia during CNS development. Here we identified miRNA-153 (miR-153) as a modulator of the temporal regulation of NSPC differentiation. Overexpression (OE) of miR-153 delayed the onset of astrogliogenesis and maintained NSPCs in an undifferentiated state in vitro and in the developing cortex. The transcription factors nuclear factor I (NFI) A and B, essential regulators of the initiation of gliogenesis, were… Expand
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