MicroRNA-149 suppresses colorectal cancer cell migration and invasion by directly targeting forkhead box transcription factor FOXM1.

@article{Xu2015MicroRNA149SC,
  title={MicroRNA-149 suppresses colorectal cancer cell migration and invasion by directly targeting forkhead box transcription factor FOXM1.},
  author={Kai Xu and Xiaobei Liu and Xiaobei Mao and Lijun Xue and Rui Wang and Longbang Chen and Xiaoyuan Chu},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2015},
  volume={35 2},
  pages={499-515}
}
BACKGROUND/AIMS The aim of this study is to investigate the clinicopathological and prognostic values of miR-149 expression and its roles in colorectal cancer (CRC) progression. METHODS qRT-PCR was performed to detect miR-149 expression in CRC cell lines or tissues. Also, the clinical significance of miR-149 expression was investigated. The study further explored whether miR-149 inhibits migration and invasion of CRC cells by targeting the mammalian Forkhead Box M1 (FOXM1). RESULTS miR-149… CONTINUE READING
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