MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.

  title={MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.},
  author={Pooja Joshi and Young-Jun Jeon and Alessandro Lagan{\`a} and Justin Middleton and Paola Secchiero and Michela Garofalo and Carlo M. Croce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 28},
Nonsmall cell lung cancer (NSCLC) is one of the leading causes of death worldwide. TNF-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in malignant cells without inducing significant toxicity in normal cells. However, several carcinomas, including lung cancer, remain resistant to TRAIL. MicroRNAs (miRNAs) are small noncoding RNAs of ∼ 24 nt that block mRNA translation and/or negatively regulate its stability. They are often aberrantly expressed in cancer and have… CONTINUE READING
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