MicroRNA-146a negatively regulates PTGS2 expression induced by Helicobacter pylori in human gastric epithelial cells

@article{Liu2012MicroRNA146aNR,
  title={MicroRNA-146a negatively regulates PTGS2 expression induced by Helicobacter pylori in human gastric epithelial cells},
  author={Zhen Liu and Di Wang and Yongliang Hu and Guoyong Zhou and Chaohui Zhu and Qi Yu and Yingchun Chi and Yingli Cao and Chi-yu Jia and Quan-ming Zou},
  journal={Journal of Gastroenterology},
  year={2012},
  volume={48},
  pages={86-92}
}
Helicobacter pylori is a major human pathogenic bacterium in the gastric mucosa, but to date the regulatory mechanism of the H. pylori-induced inflammatory response is not clear. MicroRNAs have recently emerged as key post-transcriptional regulators of gene expression. We have previously reported that miR-146a negatively regulates the H. pylori-induced inflammatory response, but its molecular mechanism is just beginning to be explored. Our aim was to further explore the key targets of miR-146a… CONTINUE READING