MicroRNA-146a inhibits epithelial mesenchymal transition in non-small cell lung cancer by targeting insulin receptor substrate 2.

@article{Park2015MicroRNA146aIE,
  title={MicroRNA-146a inhibits epithelial mesenchymal transition in non-small cell lung cancer by targeting insulin receptor substrate 2.},
  author={Dong Ho Park and Hyo Sung Jeon and Soo Young Lee and Yi Young Choi and Hae Woo Lee and Seongkyu Yoon and Jae Chel Lee and Yoo Sang Yoon and Dae Sung Kim and Moon Jun Na and Sun Jung Kwon and Dong Sun Kim and Jaeku Kang and Jae Yong Park and Ji Woong Son},
  journal={International journal of oncology},
  year={2015},
  volume={47 4},
  pages={1545-53}
}
During cancer progression, some tumor cells show changes in their plasticity by morphological and phenotypical conversions, as an expression of mesenchymal markers and loss of epithelial markers, collectively referred to as epithelial-mesenchymal transition (EMT). EMT has been increasingly recognized as a critical phenomenon in lung cancer progression. The goal of this study was to identify microRNAs involved in lung cancer progression. A microarray and qRT-PCR were performed to investigate the… CONTINUE READING
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