MicroRNA-146a downregulates NFκB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma.

@article{Paik2011MicroRNA146aDN,
  title={MicroRNA-146a downregulates NFκB activity via targeting TRAF6 and functions as a tumor suppressor having strong prognostic implications in NK/T cell lymphoma.},
  author={Jin Ho Paik and Ji-young Jang and Yoon Kyung Jeon and Wook Youn Kim and Tae Min Kim and Dae Seog DS Heo and Chul-Woo Kim},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 14},
  pages={4761-71}
}
PURPOSE We investigated prognostic implications of microRNAs in extranodal NK/T cell lymphoma (NKTL). EXPERIMENTAL DESIGN We measured miRNA expression in NKTL tissues and cell lines, using real-time PCR, and analyzed its role in NKTL, using cell lines. RESULTS Multivariate analysis showed low miR-146a expression (P < 0.001; HR = 13.110), primary non-upper aerodigestive tract lesion (non-UAT; P = 0.008; HR = 5.376) and high International Prognostic Index (IPI; ≥3; P = 0.013; HR = 3.584) to… CONTINUE READING
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